What happens in your brain when you have a psychedelic trip?

By Gabriel García August 23, 2023

Psychedelic trips are experiences that alter consciousness and perception of reality, caused by the consumption of substances such as LSD, psilocybin, mescaline or DMT. These drugs act on serotonin receptors in the brain, producing effects such as hallucinations, synesthesia, temporal distortion and ego-dissolution.

Ego dissolution is a feeling of losing the boundaries between oneself and the environment, of merging with the universe and transcending individuality. It has been compared to mystical or spiritual experiences described by some religious or cultural traditions.

Scientific studies that have analyzed the brain under the effects of psychedelics have found that these substances cause greater connectivity between different brain regions, breaking the usual functioning of specialized networks. This could explain the sensory integration, creativity and open-mindedness experienced during a trip.

Psychedelics also affect the activity of the default neural network (DNN), which is associated with reflective thinking, self-awareness and rumination. By inhibiting the NDN, psychedelics may facilitate access to unconscious, emotional or traumatic content, as well as reduce psychological distress.

Psychedelic trips may have positive long-term effects, such as increased life satisfaction, greater connection with nature, or reduced anxiety about death. However, they can also have risks, such as adverse reactions, flashbacks or psychosis. Therefore, it is important to be well informed before consuming these substances and to do so in a safe and controlled environment.

One source of useful and rigorous information on psychedelics is Argonowta’s Psychonaut’s Guides, which offer practical and scientific advice on how to prepare for, experience and benefit from psychedelic trips. These guides address topics such as dosage, set and setting, integration or legal and health precautions. If you want to know more about the fascinating world of psychedelics, we recommend that you consult these guides and explore your mind responsibly and respectfully.

The Psychonaut’s Guides from Argonowta Publishing is a collection of books that explain in a rigorous and accessible way the scientific, historical, cultural and experiential aspects of psychedelic substances. These guides offer updated and contrasted information on the therapeutic and neuroscientific applications of psilocybin, LSD, DMT and MDMA, as well as practical advice on how to prepare, carry out and take advantage of psychedelic experiences. The Psychonaut’s Guides are a must-have reference for anyone interested in learning about the psychedelic renaissance that is transforming mental health and changing lives.

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