Three psychedelic substances for legal use

By Gabriel García June 29, 2022

We recently heard the news of the release of the first trailer for Netflix’s new four-part documentary series ‘How to Change Your Mind’, based on Michael Pollan’s best-seller. With the mainstream world every day more immersed in the Psychedelic Renaissance, and awaiting regularization and legalization of the therapeutic use of these substances, in this post we have collected three legal psychedelic substances, with information about them extracted from the Essential Guide to the Psychedelic Renaissance, by Antón Gómez-Escolar, indicating in which countries and under what circumstances they are legal:


Magic truffles, or sclerotia, are nodules containing the psychedelic compound psilocybin. They are the fruit of a subway fungus, the sclerotium, which gives its name to the different varieties. They vary in taste and appearance from mushrooms, but have similar psychedelic effects. The amount of psilocybin and the potency of the effect can vary depending on the type of magic truffle consumed and the dosage. Magic truffles are considered illegal in most countries, however there are countries that allow their commercialization, so we recommend you to check the legislation regarding their use.

As Antón Gómez-Escolar says, throughout history, psilocybin mushrooms have had various religious, ritual and ritual uses. religious, ritual and shamanistic uses […] Nowadays, their use can be associated with recreational, spiritual, self-knowledge contexts and, therapeutically, they are being investigated for the therapeutic level, it is investigated for the treatment of depression, anxiety, post-traumatic stress disorder, addictions, obsessive-compulsive disorder, etc. being nowadays the psychedelic substance that is the being today the most studied psychedelic substance along with MDMA and ketamine. Like other tryptamines, it has also been used successfully in the treatment of cluster headaches for the treatment of cluster headaches.


Mescaline is a substance with a long history of ritual use, especially in Native American cultures, and was popular in some circles before the advent of LSD; though not so much in the Western world It is credited with having been in use for nearly 6000 years and is considered one of the oldest psychedelics used by humans. Its medicinal uses were studied in the 1960s, along with LSD and psilocybin, but due to its pharmacological properties it no longer has as much clinical significance as it once did. 

Currently, unlike other classic psychedelics, there is not much research on its use in clinical practice, but there is in the United States. Its use is still legal for Native Americans.


Its use, traditionally ceremonial and religious, although more of a minority than that of plants, continues to this day and has become very popular in recent times due to the potency of its effects and its legal status. It is present in many countries, although it is still rare to see it as a source of recreational use, unlike DMT. At the clinical level for its possible therapeutic uses, there are currently few observational studies. However, some have reported improvement in symptoms of depression and anxiety disorders.

The toadflax is native to California, Arizona and New Mexico, although it can also be found in parts of Mexico. Although the extraction and possession of DMT and bufotenin have been banned, the frogs’ use of hallucinogenic effects is so rare and considered so mysterious that very few cases of legal prosecution are known.

If you are interested in learning more about the past, present and future of psychedelics and the so-called Psychedelic Renaissance, we recommend the Essential Guide to the Psychedelic Renaissance, an essential guide to an essential movement. This book presents the history, neuroscience, legality, therapeutic applications and harm reduction of the most promising psychedelic drugs for science, as an introduction to this revolution that is beginning to spread around the world. The book also includes a foreword written by one of the greatest eminences in this field, Rick Doblin, founder of MAPS, the largest organization of studies on psychedelics.

The book, like the rest of the Psychonaut’s Guide series, is now available on Amazon in physical and eBook format, as well as Apple Books. In addition, all titles are available in Spanish version on

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